It is possible that the main title of the report Tongue Cancer is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Tongue cancers are oral cancers that are differentiated by their location in the mouth and on the tongue. If the cancer is on the forward portion of the tongue, it is known as a squamous cell cancer of the oral tongue. If the cancer is located towards the rear third of the tongue, it is known as a squamous cell cancer at the base of the tongue.
The characteristics of these two cancers are quite distinct, and reflect the differences in their origins. The difference in origins is also the reason that the treatment of these two forms of tongue cancer is quite different. Oral cancers are relatively rare, representing only about three percent of all cancers.
Persons with periodontitis who also are infected with human papillomavirus (HPV) are at increased risk of developing tongue cancer, new research conducted at the University at Buffalo School of Dental Medicine has shown.
Periodontitis is a chronic inflammatory disease that destroys connective tissue and bone supporting the teeth. It has been associated with various systemic diseases, including diabetes and heart disease.
Researchers from UB and Roswell Park Cancer Institute published the first study showing an association between long-standing periodontitis and risk of tongue cancer in the May 2007 issue of Archives of Otolaryngology - Head and Neck Surgery. Studies conducted elsewhere have found that HPV is an independent risk factor for a subset of head and neck cancers. The UB researchers now have shown that the two infections appear to work in tandem to boost the chances of developing tongue cancer.
Evidence of periodontitis-HPV synergy has important practical implications,' said Tezal, 'because there is a safe treatment for periodontitis, but no treatment for HPV infection. If these results are confirmed by other studies, this has a tremendous relevance in predicting and intervening in the initiation and prognosis of HPV-related diseases, including head and neck cancers.'
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